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Drug-target interaction network

Dataset information

This is a drug-target interaction network that contains information on which genes (i.e., proteins encoded by genes) are targeted by drugs that are on the U.S. market. Drug targets are molecules that play a critical role in the transport, delivery or activation of the drug. Drug target information is widely used to facilitate computational drug target discovery, drug design, drug docking or screening, drug metabolism prediction, drug interaction prediction, and general pharmaceutical research.


Dataset statistics
Nodes 7341
Drug nodes 5017
Gene nodes 2324
Edges 15138
Nodes in largest SCC 6621
Fraction of nodes in largest SCC 1.000000
Edges in largest SCC 14581
Fraction of edges in largest SCC 0.963205
Diameter (longest shortest path) 15
90-percentile effective diameter 7.884931

Drug target information includes biotech drugs and nutraceuticals (these drugs on average have 5-10 unique target proteins), lists all targets that have been found to have physiological or pharmaceutical effects (not only a single primary target), and fully accounts for the fact that many drug targets are protein complexes composed of multiple subunits or combinations of proteins.

References


Files

File Size Description
ChG-Miner_miner-chem-gene.tsv.gz 307KB Drug-target interaction network (edgelist)